Teresa's brothers, Lorenzo, Jeronimo and Pedro left for America on the 5th of November 1540. 

Pedro (b.1521) was a very difficult person to deal with and tried Teresa's patience greatly.  He returned to Spain after his wife's death, however was unable to support himself and was cared for by Lorenzo at Teresa's request, ending his days on his brother's estate near Avila.

Jeronimo de Cepeda (1522 - 75).  Again, Teresa felt the need to look after this brother also, urging Lorenzo to provide financially for an illegitamit daughter.  Jeronimo decided to return to Spain due to bad health but died on the voyage back.

Lorenzo de Cepeda (1519 - 80).  Lorenzo was the brother who helped Teresa most, especially following his return from Ecuador.  He was only 21 when he left.  He made his fortune there and his financial help aided Teresa greatly in her foundations amongst many other requests.  They were very close and she acted very much as his spiritual director throughout their correspondance.  She rejoiced to see virtues coming to fruition in his life.  He returned to Spain after the death of his wife, anxious that his children be well educated.  Teresa recommended Avila as an excellent place for their education.  At home he retired to a farm in the country near Avila dedicating his life to prayer.  He died of influenza in 1580.

Teresa was greatly concerned about the spiritual good of her brothers and was overjoyed to see them following the way of light. 

'...one of the great favours the Lord has granted me is that he has given you understanding of what the world is, and so you have chosen to live quiet lifes.  Now I know, too, that you have taken the path of heaven.  This is what I wanted most to know, for up until now I was always in dread.  Glory to the One who does all.  May it please him that you always advance in his service.  Since there is no measure to his remunerations, we should never stop trying to serve the Lord.  Each day we will advance at least a little further, and with fervour.  It seems, and so it is, that we are always at war, and until we are victorious, we must not grow careless.'

In writing to her sister Juana, she delights in the growth of Lorenzo's good charactor.

'Do you see now what God is working in Lorenzo de Cepeda?  He seems to be looking more to his children's salvation that to amassing a fortune.  O Jesus, how much I owe you - everywhere that I look - and how little I serve you!  No happiness for me is greater than to see my brothers, whom I love so much, receive the light to desire what is best.  Didn't I tell you to leave it all in the Lord's hands, that he would take care of it?  So I advise you again to place your affairs in his hands, for in everything His Majesty will do what most suits us.'